贵州福彩网

Tailor-made Nanobody

Nanobodies: Because of their small size, high affinity, high safe protein materials, access to enzymatic active sites to provide potent enzyme inhibition, Nanobodies can be ideal alternative agents to small molecular chemicals.


贵州福彩网A novel type of antibody fragment, termed camel single-domain antibody fragments (VHH) or Nanobody, is derived from heavy-chain antibodies, which are present in sera of camelids such as camels, llamas, alpacas and dromedaries. With the average size of 15 kDa, Nanobodies are the smallest naturally occurring integral antigen binding units with a longer CDR3 which can form a convex conformation. This conformation allows nanobodies to bind to previously unreachable conformations active sites of enzymes, or nucleic acid conformations. Therefore, nanobodies will be the hopeful candidates in the field of future antibodies. These properties make Nanobodies advantageous for diagnostic and therapeutic drugs in the fields of infectious diseases (AIDS, hepatitis, malaria), metabolic diseases (diabetes), or oncology (colon and breast cancers). Gegen has constructed the Nanobody libraries and camelizd human ScFv and Fab antibody libraries.

 

贵州福彩网Nanobodies for cell cycle, organelle physiological function, cell membrane ion channel, mRNA and RNAi dynamic changes, gene editing process and other aspects can be screened from our Nanobody libraries. We provide custome services:

贵州福彩网1. Preparation of bi-specific nanobodies

贵州福彩网2. Single-domain antibody(Nanobody) library construction

3. Nanobody affinity maturation service

4. Preparation of human and/or humanized nanobodies

5. Nanobodies for membrane proteins

6. Preparation of nanobodies capable crossing the blood-brain barrier


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